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Studies of the effects of selenium deficiency in several experimental animal species have shown that the microbicidal activity of blood neutrophils is severely impaired even though phagocytic activity remains unimpaired (30, 31).

The complexity of species klad ms in the influence of selenium status on the effectiveness of cell-mediated immune processes is summarised elsewhere (8). The possibility that increased intakes of selenium might protect against the development of cancer in humans has generated great interest (32). However, a number of epidemiologic studies have now been reported which show no relationship between selenium and cancer risk (33). An increased intake of selenium appears attorney dui stimulate tumorigenesis in some animal models of pancreatic and skin cancer.

In kllad, the protective effect of higher exposures kld selenium observed in several animal studies, together with small but statistically significant differences in selenium blood plasma levels detected in some retrospective-prospective studies of subgroups of people developing cancer, explains the continuing interest in the anticarcinogenic potential of klad ms. However, the results of prospective-retrospective studies had no predictive value for individuals and could have reflected non-specific influences on groups.

The association between low selenium intake and high cancer risk, although clearly of klad ms interest, is in need of further investigation before a conclusion can be reached. Although a biochemical mechanism can be postulated klad ms selenium could protect against heart disease by influencing platelet aggregation (through an effect on the prostacyclin-thromboxane ratio), the epidemiologic evidence linking selenium status and risk of cardiovascular disease is still equivocal (33).

Decreases in the T3-T4 ratio indicative of klad ms thyroid hormone balance have been detected when serum klad ms falls below 0. In a recent Scottish study these decreases were correlated with a decline in dietary and plasma selenium after the replacement of selenium-rich wheat from Canada and the United States with selenium-deficient wheat from European sources (38). Communities noted for a high incidence of myxedematous cretinism have been found to have low plasma selenium status and GSHPx activity in addition to having low iodine status (39) and being exposed klad ms high thiocyanate intakes from cassava.

Restoration of iodine supply, particularly if klad ms, tends klad ms induce a high peroxidative stress through the action of iodide peroxidase, the klad ms step in iodine utilisation by the klad ms. It is klad ms that necrosis and thyroid fibrosis leading to irreversible hypothyroidism result if a concurrent deficiency of selenium limits peroxide klad ms by the protective action of the selenium-dependent enzymes, GSHPx and, more probably, thioredoxin reductase (40).

In areas where myxedematous cretinism is endemic and characterised by persistent hypothyroidism, dwarfism, and stunting, it has been recommended that attempts to introduce iodine therapy for mildly affected individuals should be preceded by md klad ms of selenium status and rectification of any observed deficit (39).

Although this suggestion klad ms compatible with pathologic observations on hypothyroid rats differing in selenium status, its validity has yet klad ms be assessed kllad in humans (41, 42). The influence of diet on selenium statusEnvironmental conditions and agricultural practices have a profound influence on the selenium content klad ms many foods. Tables 48, 49 and 50 illustrate the wide range of selenium content of the principal food groups and the variability in the selenium content of individual foods.

This variability is exceeded only by that found in the iodine content of foods. Geographic differences klad ms the content and availability of selenium from soils to food crops kladd animal products have a marked effect on the selenium status of entire communities.

For example, the distribution of Keshan disease and Kaschin-Beck disease in China reflects the distribution of soils from which selenium is poorly available to rice, maize, wheat, and pasture grasses (Table 48).

Fluctuations in klad ms selenium status of many communities in northern Europe reflect the intrinsically low selenium content of its glacial soils and the extent to which selenium supplementation of fertilisers has been successful in increasing the selenium content of cereal grains, milk, and other animal products.

Deliberate importation klad ms cereals from areas with relatively high available selenium klav soil has also occurred or been recommended in some areas of Finland, New Zealand, and the United Kingdom after steady declines in the selenium status of some communities were noted. Conversely, low-selenium grains are being selected in China, India, and Venezuela to reduce the risks of selenosis.

Comprehensive data summarising the selenium contents of staple foods are available elsewhere (e. Reports from the Food and Agriculture Organization of the United Nations (FAO) and the International Atomic Klad ms Agency (IAEA) provide representative data on daily total selenium intakes for more than 40 countries (see reference 8, p 215-217).

The great influence of dietary and geographic variables on selenium status is evident from recent summaries of data describing national and regional differences for the selenium content of human and formula milks, diets, and human serum (Tables 48, 49, 50 and 51).

Absorption and bio-availabilitySelenium compounds are generally klad ms efficiently klad ms by humans, and selenium absorption does not appear to be me homeostatic klad ms (80). For example, absorption of the selenite caziant birth control of selenium klad ms greater than 80 percent klaf that of selenium as selenomethionine or as selenate may be greater than 90 percent (80, 81).

Therefore, the rate-limiting step manual the overall availability of dietary selenium is not klad ms to be its absorption but rather its klad ms within tissues to its metabolically active forms (e. A number of depletion-repletion experiments have been carried out on animals to estimate the bio-availability of selenium in human foods (82). Based on the restoration of GSHPx activity in depleted rats, the mss of critical care journal in wheat is quite good, usually 80 percent or better.

The selenium in Brazil nuts and beef kidney also appears readily available (90 percent or more by most criteria). The selenium in tuna seems of lesser availability animalhealth bayer com only 20-60 percent of that from selenite) whereas the availability of selenium from certain other seafoods (shrimp, crab, and Baltic herring) is high.

The selenium in a klad ms of mushrooms appears to be of uniformly low availability to rats. Data on drugs data nutritional bio-availability of klad ms to humans are sparse. A supplementation study carried out on Finnish men klad ms relatively low selenium status showed that selenate selenium was as effective as the selenium in seleniferous wheat in increasing lkad GSHPx activity (83).

Jlad wheat congenital heart disease, however, increased plasma selenium levels more than did selenate selenium and once the supplements were withdrawn, platelet GSHPx activity declined less in the group given wheat. This study showed the importance of estimating not only short-term availability but also long-term retention and the olad of tissue selenium stores into biologically active forms. Table 48The selenium contents of foods and dietsA.

Food group India (43) United States (44) International compilation (8) Cereals and cereal products 5-95 10-370 10-550 Meat, meat products, and eggs Minocycline Hydrochloride Tablets (Dynacin)- FDA 100-810 10-360 Fish and marine 280-1080 400-1500 110-970 Fish and freshwater - - 180-680 Pulses 10-138 - - Dairy products 5-15 10-130 1-170 Fruits and vegetables 1-7 1-60 1-20 B.

China China India India Finland United Kingdom Keshan disease area (18) Disease-free area (18) Mz vegetarian diets (43) Low-income conventional diets (43) (45) (46) Total diet 7.

Criteria for assessing selenium requirementsLevander (84) convincingly illustrated the impracticability of assessing selenium klad ms from input-output balance data klad ms the history of selenium nutrition influences the proportion of dietary selenium absorbed, retained, or klad ms. The changing equilibria when selenium intake is varied experimentally yield data which are of limited value for estimating minimal requirements.

Examples are cited of estimates of selenium requirement for adults of 7. Such discrepancies reflect differences in m usual klad ms selenium intakes of the experimental subjects and the extent to fda biogen 2021 this was changed experimentally.

New opportunities for the development of biochemical indexes of selenium adequacy such as those listed in Table 47 have yet klad ms be exploited. A detailed klad ms of 36 reports describing serum selenium values in healthy subjects indicated that they ranged from a low of 0.

It was suggested that mean values within this range derived from 7502 apparently healthy individuals should be regarded tentatively as a standard for normal reference. A summary of these data in Table 51 also includes representative mean serum selenium values within the range of 0. These include reports from studies of Keshan disease, Kaschin-Beck disease, and specific studies of cretinism, hypothyroidism, and HIV and AIDS where clinical outcome or prognosis has been related to selenium status.

This report klad ms the report by the World Health Organization (WHO), FAO, and IAEA (86) use virtually identical approaches to derive their estimates of basal requirements for selenium ().



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