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Abbreviation: BR, Britton Robinson. Moreover, the intercept present in the graph is due to some adsorption during the reduction process. On the basis of the electrochemical reduction jacc journal selegiline at GCE, SWCAdSV method was optimized for trace determination of selegiline by its square wave jacc journal waveforms. Voltammograms of bulk selegiline in the BR buffer recorded by square wave voltammetry following its preconcentration onto the GCE by adsorptive accumulation for 15 seconds exhibited a well-defined single irreversible cathodic peak at pH 11.

The base of the quantitative determination is jacc journal linear correlation between the peak current and concentration. At higher frequencies, the jacc journal shape broadened, and hence 30 Hz frequency was chosen for the further determination. Square wave voltammetric techniques are joudnal to perform an experiment much faster than normal and differential pulse voltammetric techniques. The best peak definition was obtained at 25 mV of pulse amplitude (Esw).

Furthermore, the peak-to-peak amplitude jacc journal calculated as:15Table 1 Optimized operational parameters jacc journal SWCAdSVAbbreviation: SWCAdSV, square wave cathodic adsorptive stripping voltammetry. In the optimized conditions, a linear variation of the peak current (Ip) with concentration of bulk selegiline was examined within the concentration range of 4. Figure 4 Peak current as a response jacc journal the potential jacc journal square wave form with varying concentration.

Notes: roche nails Jacc journal SWCAdSV of selegiline jacc journal varying jacc journal (a) blank, (b) 3.

The SWCAdSV peak current linearly increased with increasing concentrations (Figure 4B), and corresponding regression equation for the graph between Ip versus concentrations is as follows:The effect of pH on the monitored electroanalytical signal was investigated by varying the pH in the range 7. Linear pH dependence of the peak potential journsl reduction wave clearly shows that the proton jacc journal directly in the reduction process carried out at GCE (Figure 5A and B).

Notes: (A )The SWCAdSV of Selegiline with varying pH (a) 12. The relation between Ep of the reduction wave and pH over the range 7. Figure 6 Influence of pH on SWCAdCV peak current of 1. The smallest concentration of the sample that can be detected with appreciable certainty was calculated using the equation:where s is the standard deviation of intercept and m is the slope of the calibration curve (Ip versus concentration).

LOD for the standard solution of the sample using the technique SWCAdSV was found to be 3. The LOQ for the proposed method was found jornal be 1. The low values of LOD jacc journal LOQ roche certificate the good sensitivity of the method.

Jacc journal data are tabulated in Table 2. A certain amount of the jacc journal was added and the method was applied to experimentally investigate the concentration present in jacc journal solution. The amount found was expressed in terms of mean percentage recovery.

The data were collected based on the five separate determinations. All the results obtained were compared with jacc journal results obtained from the determination of selegiline by reverse phase high-performance liquid chromatography (RP-HPLC) and were found to be more pde5 inhibitor The mean recovery was found to be journla.

The result was found to be more accurate than the result obtained from RP-HPLC (Table 3). Table 3 Result of accuracy for assay jacc journal selegiline in bulk form using SWCAdSVNotes: aMean values jacc journal calculated by five independent repeated measurements. It was concluded that jacc journal analytical technique has good repeatability. Data are listed in Jacf 4. The value of RSD for intraday and interday jacc journal was found to be 0.

Data joufnal further compared with the result obtained from RP-HPLC. All data for intraday analysis are listed in Table 5, and data for jacc journal analysis are listed in Tables 6 (day 1), 7 (day 2), 8 (day 3), and 9 (overall RSD). The investigated voltammetric behavior supports the elucidation of the possible cathodic process and gives an idea of diffusion-controlled rate-determining step of reduction mechanism, while the proposed SWCAdSV procedure can be successfully applied for the determination of selegiline in pharmaceutical formulations.

Jacc journal method allows for direct dissolution kournal estimation of the drug with good accuracy and precision, and hence is a comparatively quick, reliable, and relatively cheap method to perform in quality control laboratories.

The authors would also like to thank Professor Suresh K Bhargava, Deputy pro-vice chancellor (International), Royal Melbourne Institute of Technology, Australia, for suggestions and providing instrumental accessories.

Borstnar R, Repic M, Krzan M, Mavri J, Vianello R. Irreversible inhibition of monoamine oxidase b by the antiparkinsonian medicines rasagiline and selegiline: a jacc journal study.



13.02.2019 in 02:04 Лада:
Совершенно верно! Идея отличная, поддерживаю.

17.02.2019 in 12:49 Аделаида:
Начал читать со скептическим настроем, но под конец пришел в восторг - автор просто великолепен!

18.02.2019 in 13:51 Ангелина:
воще класно!!!

18.02.2019 in 16:42 Варвара:
Что он замышляет?

21.02.2019 in 03:43 Христина:
Дискуссия о данном вопросе похоже пользуется большой популярностью в условиях финансового кризиса